DESCRIPTION
  • Botanical name:
  • Common names:
  • Source:
Uncaria tomentosa (Rubiaceae)
Uña de Gato, cat's claw, samento, uña huasca, saventaro.
The leaves and bark of wild growing Uncaria tomentosa. A large twining shrub that grows in the Peruvian upland Rainforest. Sustainable managed and collected by native communities.
 

TRADITIONAL USE
Native people of the Central Peruvian Amazon upland rainforest use it since centuries ago. Cooked bark and root are used for the treatment of inflammatory diseases and neoplasy. It is used to heal wounds, as a powerful immune system booster, and in inflammatory processes of different kinds in organs and/or systems, skin inflammations as well as in the urinary tract.

 
MODERN Applications
  • Anti-inflammatory
  • Immune system booster.
  • Market presentation: powder in capsules and tablets.


TECHNICAL INFORMATION


CAT´S CLAW / UÑA DE GATO
(Uncaria tomentosa)
Spray-dried extract

PRODUCT CODE
CWBX12
COMPOSITION
Dried bark of Uncaria tomentosa
DESCRIPTION
Main active ingredients:
Oxindole alkaloids, Mitraphyllin
Aspect:
Fine powder
Color:
Light brown
Taste and odor:
Bitter, characteristic flavor and odor
Type of extraction:
Hydroalcoholic. Spray-dried
Concentration:
12:1 12kg dried Cat´s claw bark / 1kg spray-dried extract
Packaging
3Kg bi-layered Nylon/PE bags in hard corrugated paper boxes
PHYSICAL AND CHEMICAL ESPECIFICATIONS
Total Oxindole Alkaloids
Minimum 3.0%*
Solubility
99% soluble in water. Hygroscopic


REFERENCES

  • Eberlin, S., et al. “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes.” Int. Immunopharmacol. 2005; 5(7-8):1235-46.
  • Lamm, S., et al, “Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100." Phytomedicine. 2001; 8(4): 267–74.
  • Sheng Y, et al., “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.” Phytomedicine. 2000; 7(2): 137–43.
  • Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato).” J. Ethnopharmacol. 1999; 64(2): 109–15.
  • Marina, M. D. “Evaluacion de la actividal immunoestimulante de Uncaria tomentosa (Willd.) DC. Una de gato en ratones albinos." Biodiversidad Salud. 1998; 1(1): 16–19.
  • Wagner, H., et al. “Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung." Planta Med. 1985; 51: 419–23.
  • Hardin, S. R. "Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis." Complement. Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
  • Allen-Hall, L., et al. "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha." J. Ethnopharmacol. 2007 Jan; 109(2): 312-7.
  • Sheng, Y., et al. “An active ingredient of Cat's Claw water extracts: identification and efficacy of quinic acid.” J. Ethnopharmacol. 2005 Jan 15; 96(3)
  • Aguilar, J. L., et al. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” J. Ethnopharmacol. 2002; 81(2): 271–76.
  • Sandoval, M., et al., “Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content." Phytomedicine. 2002; 9(4): 325–37.
  • Mur, E., et al. “Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis.” J. Rheumatol. 2002 Apr; 29(4): 678–81.
  • Sandoval-Chacon, M., et al. “Anti-inflammatory actions of cat’s claw: the role of NF-kappaB.” Aliment. Pharmacol. Ther. 1998; 12(12): 1279–89.
  • Aquino, R., et al. “Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa." J. Nat. Prod. 1991; 54: 453–59.
  • Cerri, R., et al. “New quinovic acid glycosides from Uncaria tomentosa." J. Nat. Prod. 1988; 51: 257–61.
  • Gonzales, G.F., et al. "Medicinal plants from Peru: a review of plants as potential agents against cancer." Anticancer Agents Med. Chem. 2006 Sep; 6(5): 429-44.
  • De Martino, L., et al. "Proapoptotic effect of Uncaria tomentosa extracts." J. Ethnopharmacol. 2006 Aug; 107(1): 91-4.
  • Bacher, N., et al. "Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells." Br. J. Haematol. 2006 Mar; 132(5): 615-22.
  • Riva, L., et al. “The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line." Anticancer Res. 2001; 21(4A): 2457–61.
  • Muhammad, I., et al. “Investigation of Una de Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa." Phytochemistry. 2001; 57(5): 781–5.
  • Sheng, Y., et al. “Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa." Anticancer Res. 1998; 18(5A): 3363–68.
  • Rizzi, R., et al. “Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts." J. Ethnopharmacol. 1993; 38: 63–77.
  • Peluso, G., et al. “Effetto antiproliferativo su cellule tumorali di estrattie metaboliti da Uncaria tomentosa. Studi in vitro sulla loro azione DNA polimerasi.” 11 Congreso Italo-Peruano de Etnomedicina Andina, Lima, Peru, October 27–30, 1993, 21–2.
  • Rizzi, R., et al. “Bacterial cytotoxicity, mutagenicity and antimutagenicity of Uncaria tomentosa and its extracts. Antimutagenic activity of Uncaria tomentosa in humans." Premiere Colloque Européan d'Ethnopharmacologie, Metz, France, March 22–24, 1990.
  • Mammone, T., et al. "A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin." Phytother. Res. 2006; 20(3): 178-83.
  • Pilarski, R., et al. "Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC." J. Ethnopharmacol. 2006 Mar; 104(1-2): 18-23.
  • Cisneros, F. J., et al. “An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation.” J. Ethnopharmacol. 2005 Jan; 96(3): 355-64.
  • Goncalves, C., et al. “Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity.” Phytochemistry. 2005; 66(1): 89-98.
  • Pilarski, R., et al. “Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC.” J. Ethnopharmacol. 2005 Sep 29;
  • Sheng, Y., et al. “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study." Phytomedicine. 2001; 8(4): 275–82.
  • Sheng, Y., et al. “Enhanced DNA repair, immune function and reduced toxicity of C-Med-100, a novel aqueous extract from Uncaria tomentosa." J. Ethnopharmacol. 2000; 69(2): 115–26.
  • Sandoval, M., et al. “Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.” Free Radic. Biol. Med. 2000; 29(1): 71–8.
  • Desmarchelier, C., et al. “Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC." Phytother. Res. 1997; 11(3): 254–256.
  • Jurgensen, S., et al. “Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.” Pharmacol. Biochem. Behav. 2005 Jul; 81(3): 466-77.
  • Mohamed, A. F., et al. “Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.” J. Pharm. Pharmacol. 2001; 52(12): 1553–61.
  • Aquino, R., et al. “Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda." J. Nat. Prod. 1989; 4(52): 679–85.

 

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